Glycine betaine, a beer component, protects radiation-induced injury.

نویسندگان

  • Manami Monobe
  • Akiko Uzawa
  • Makiko Hino
  • Koichi Ando
  • Shuji Kojima
چکیده

Human whole-blood was exposed to 137Cs gamma-rays or 50 keV/microm carbon ions in the presence or absence of glycine betaine, a beer component in vitro. The dicentrics of chromosome aberrations in human lymphocytes were significantly (p < 0.05) reduced by glycine betaine after irradiation with 4 Gy of either gamma-rays or carbon ions. The maximum protection by glycine betaine for gamma-rays or carbon ions was 37% and 20%, respectively. C3H/He female mice, aged 14 weeks, received an i.p. injection of glycine betaine 15 min before whole-body irradiation with gamma-rays or 50 keV/microm carbon ions. Glycine betaine significantly (p < 0.05) increased the percent survival of irradiated mice with either gamma-rays or carbon ions. In conclusion, glycine betaine is a potent protector against damages caused by low- and high-LET radiation.

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عنوان ژورنال:
  • Journal of radiation research

دوره 46 1  شماره 

صفحات  -

تاریخ انتشار 2005